(7R,8S,8aS)-8-Hydroxy-7-phenylperhydroindolizin-3-one
نویسندگان
چکیده
In the title compound, C(14)H(17)NO(2), the six-membered ring of the indolizine system adopts a chair conformation. In the crystal, mol-ecules form chains parallel to the b axis via inter-molecular O-H⋯O hydrogen bonds. The absolute mol-ecular configuration was assigned from the synthesis.
منابع مشابه
(7R,8R,8aS)-8-Hydroxy-7-phenylperhydroindolizin-3-one
The absolute configuration of the title compound, C(14)H(17)NO(2), was assigned from the synthesis. There are two mol-ecules in the asymmetric unit. Their geometries are very similar and corresponding bond lengths are almost identical [mean deviation for all non-H atoms = 0.015 (2) Å]. The six-membered ring of the indolizine system adopts a chair conformation. In the crystal structure, mol-ecul...
متن کاملLignan Glycosides from Gentianella acuta (Michx.) Hulten. and Their Protective Effects Against H2O2-Induced Apoptosis in H9c2 Cardiomyoblasts
Two new lignan glycosides named acutosides A (1) and B (2) have been isolated from the whole plant of Gentianella acute (Michx) Hulten. and their structures were determined as (-)-(7R,8S,7'E)-4-hydroxy-3,3'dimethoxy-7,4'-epoxy-8,5'-neolign-7'-ene-9,9'-diol 9'-ethyl ether-4-O-β-D-glucopyranoside and (-)-(7R,8S,7'E)4-hydroxy-3,3'-dimethoxy-7,4'-epoxy-8,5'-neolign-7'-ene-9,9'-diol 9-ethyl ether-9'...
متن کاملEnantioselective synthesis of an octahydroindolizine (indolizidine) alcohol using an enzymatic resolution.
A homo-chiral synthesis of (7R,8aS)-octahydro-5,5-dimethylindolizin-7-amine 8 and (7S, 8aS)-octahydro-5,5-dimethylindolizin-7-ol 9, amine building blocks which have found applications within the pharmaceutical industry, is presented. The approach uses a Novozym 435-mediated kinetic resolution of racemic octahydroindolizine (indolizidine) alcohol 13 as a key step (up to 100 g scale).
متن کاملLignans from Leaves of Juniperus Chinensis
Umbelliferone, 13 lignans and an unusual compound 2-(3,4-methylenedioxyphenyl)propane-1,3-diol, were isolated from the leaves of Juniperus chinensis. The lignans include meso-secoisolariciresinol, 3,4-methylenedioxy-3’,4’dimethoxylignan-9’,9-olide, hibalactone, isohibalactone, 7-oxohinokinin, 7-hydroxyhinokinin, 7-acetyloxyhinokinin, (+ )-xanthoxylol, dihydrodehydrodiconiferyl alcohol, 3-methox...
متن کاملSyntheses and antimicrobial activity of tetrasubstituted tetrahydrofuran lignan stereoisomers.
The syntheses of all stereoisomers of tetrasubstituted tetrahydrofuran lignan were accomplished, and the antimicrobial activity was examined. The 9,9'-diol compound bearing (7R,7'R,8R,8'R) and (7R,7'S,8R,8'R) stereochemistry showed the strongest antibacterial activity against Listeria denitrificans and Bacillus subtilis, respectively. It was also found that (-)-virgatusin bearing (7S,7'R,8S,8'S...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 65 شماره
صفحات -
تاریخ انتشار 2009